MolNFT v1 · #112300 · protein

Structural basis of lewisb antigen binding by the helicobacter pylori adhesin baba

4ZH7 · Outer membrane protein-adhesin: “Structural basis of lewisb antigen binding by the helicobacter pylori adhesin baba”. X-ray diffraction, 3 ligands (GAL, FUC, NAG), 3 pockets (best druggability 0.46). MolNFT v1 #112300 on GenesisL1…

PDB: 4ZH7
Type: protein
Length: 485 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Outer membrane protein-adhesin
UniProt: Q9ZKV2
Ligands: GAL, FUC, NAG
Pockets: 3 · best druggability 0.46

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Outer membrane protein-adhesin	protein	485	52% helix, 17% strand	Q9ZKV2

Ligands and binding sites

GAL · beta-D-galactopyranose · sugar · 2 copies · chains A
FUC · alpha-L-fucopyranose · sugar · 2 copies · chains A
NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	179	0.46	0.75	29	empty
2	64	0.36	0.78	17	empty
3	55	0.32	0.77	18	empty

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

4ZH7 · Structural basis of Lewisb antigen binding by the Helicobacter pylori adhesin BabA · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9ZKV2
Elsewhere: RCSB PDB 4ZH7 · PDBe 4ZH7 · UniProt Q9ZKV2

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.