MolNFT v1 · #112284 · protein
Structure of CDC123 bound to EIF2-gammadiii domain
4ZGQ · Cell division cycle protein 123: “Structure of CDC123 bound to EIF2-gammadiii domain”. X-ray diffraction, 4 pockets (best druggability 0.73). MolNFT v1 #112284 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4ZGQ
- Type
- protein
- Length
- 374 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cell division cycle protein 123; Eukaryotic translation initiation factor 2 subunit gamma
- UniProt
- Q9P7N5, P32481
- Pockets
- 4 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cell division cycle protein 123 | protein | 272 | 36% helix, 18% strand | Q9P7N5 |
| B | Eukaryotic translation initiation factor 2 subunit gamma | protein | 102 | 0% helix, 63% strand | P32481 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 442 | 0.73 | 0.82 | 42 | empty |
| 2 | 87 | 0.43 | 0.79 | 18 | empty |
| 3 | 61 | 0.33 | 0.76 | 17 | empty |
| 4 | 50 | 0.28 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 799 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 4ZGQ · Structure of Cdc123 bound to eIF2-gammaDIII domain · the same entry in another collection · chain A against A, TM-score 1.00
- P32481 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 2 subunit… · a predicted model of the same protein · chain B against A, TM-score 0.93
- Q9P7N5 · AlphaFold monomer V2.0 prediction for cell division cycle protein 123 (Q9P7N5) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9P7N5
- Every structure of UniProt P32481
- Elsewhere: RCSB PDB 4ZGQ · PDBe 4ZGQ · UniProt Q9P7N5 · UniProt P32481
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