UniProt P32481
Eukaryotic translation initiation factor 2 subunit gamma (P32481)
Eukaryotic translation initiation factor 2 subunit gamma (UniProt P32481), EC 3.6.5.3: 23 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 5 pockets. Binding sites, druggability and experiment against…
- UniProt
- P32481
- Protein
- Eukaryotic translation initiation factor 2 subunit gamma
- EC
- 3.6.5.3
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 5 · 1 record with a druggable one
Structures
24 records of P32481 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3J81 | CryoEM structure of a partial yeast 48S preinitiation complex | electron microscopy | k | — | — |
| 3J81 | Cryoem structure of a partial yeast 48S preinitiation complex | electron microscopy | k | — | — |
| 3JAP | Structure of a partial yeast 48S preinitiation complex in closed conformation | electron microscopy | k | — | — |
| 3JAP | Structure of a partial yeast 48S preinitiation complex in closed conformation | electron microscopy | k | — | — |
| 3JAQ | Structure of a partial yeast 48S preinitiation complex in open conformation | electron microscopy | k | — | — |
| 4ZGN | Structure Cdc123 complexed with the C-terminal domain of eIF2gamma | x-ray diffraction | B | — | 1 (best 0.47) |
| 4ZGN | Structure CDC123 complexed with the C-terminal domain of EIF2GAMMA | x-ray diffraction | B | — | — |
| 4ZGQ | Structure of Cdc123 bound to eIF2-gammaDIII domain | x-ray diffraction | B | — | 2 (best 0.43) |
| 4ZGQ | Structure of CDC123 bound to EIF2-gammadiii domain | x-ray diffraction | B | — | — |
| 6GSM | Structure of a partial yeast 48S preinitiation complex in open conformation. | electron microscopy | k | 7NO, MG, GCP | — |
| 6I3M | EIF2B:EIF2 complex, phosphorylated on EIF2 alpha serine 52. | electron microscopy | O, P | — | — |
| 6I7T | EIF2B:EIF2 complex | electron microscopy | O, P | — | — |
| 6QG0 | Structure of EIF2B-EIF2 (phosphorylated at SER51) complex (model 1) | electron microscopy | M, N | — | — |
| 6QG1 | Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model 2) | electron microscopy | M, N | — | 2 (best 0.75) |
| 6QG1 | Structure of EIF2B-EIF2 (phosphorylated at SER51) complex (model 2) | electron microscopy | M, N | — | — |
| 6QG2 | Structure of EIF2B-EIF2 (phosphorylated at SER51) complex (model a) | electron microscopy | M, N | — | — |
| 6QG3 | Structure of EIF2B-EIF2 (phosphorylated at SER51) complex (model B) | electron microscopy | M, N | — | — |
| 6QG5 | Structure of EIF2B-EIF2 (phosphorylated at SER51) complex (model C) | electron microscopy | M, N | — | — |
| 6QG6 | Structure of EIF2B-EIF2 (phosphorylated at SER51) complex (model D) | electron microscopy | M, N | — | — |
| 8RW1 | Structure of a yeast 48S-AUC preinitiation complex in closed conformation | electron microscopy | k | GCP, MET | — |
| 8S8D | Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-2) | electron microscopy | k | GCP, MG, MET | — |
| 8S8H | Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-2.2) | electron microscopy | k | GCP, MG, MET | — |
| 8S8J | Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-eIF5) | electron microscopy | k | MET, GCP, MG | — |
| P32481 | AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 2 subunit gamma… | predicted | A | — | — |
Ligands
Experiment against prediction
- 8S8H chain k against the predicted model P32481: TM-score 0.98, RMSD 1.27 Å
- 8S8J chain k against the predicted model P32481: TM-score 0.97, RMSD 1.31 Å
- 8S8D chain k against the predicted model P32481: TM-score 0.97, RMSD 1.31 Å
- 8RW1 chain k against the predicted model P32481: TM-score 0.97, RMSD 1.37 Å
- 3J81 chain k against the predicted model P32481: TM-score 0.97, RMSD 1.29 Å
- 3J81 chain k against the predicted model P32481: TM-score 0.97, RMSD 1.29 Å
- 6I7T chain O against the predicted model P32481: TM-score 0.97, RMSD 1.42 Å
- 6I3M chain O against the predicted model P32481: TM-score 0.97, RMSD 1.42 Å
- 3JAP chain k against the predicted model P32481: TM-score 0.96, RMSD 1.42 Å
- 3JAP chain k against the predicted model P32481: TM-score 0.96, RMSD 1.42 Å
Elsewhere
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