MolNFT v1 · #111839 · protein
Crystal structure of human SPT16 mid-AID/H3-H4 tetramer fact histone complex
4Z2M · Fact complex subunit SPT16: “Crystal structure of human SPT16 mid-AID/H3-H4 tetramer fact histone complex”. X-ray diffraction, 5 pockets (best druggability 0.67). MolNFT v1 #111839 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4Z2M
- Type
- protein
- Length
- 565 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fact complex subunit SPT16; Histone H3.1; Histone H4
- UniProt
- Q9Y5B9, P68431, P62805
- Pockets
- 5 · best druggability 0.67
Structure
x-ray diffraction · 5 distinct chains · 45% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Fact complex subunit SPT16 | protein | 271 | 24% helix, 38% strand | Q9Y5B9 |
| G | Histone H3.1 | protein | 77 | 64% helix, 5% strand | P68431 |
| H | Histone H4 | protein | 71 | 66% helix, 7% strand | P62805 |
| I | Histone H3.1 | protein | 76 | 67% helix, 5% strand | P68431 |
| J | Histone H4 | protein | 70 | 60% helix, 6% strand | P62805 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 607 | 0.67 | 0.77 | 53 | empty |
| 2 | 206 | 0.51 | 0.77 | 20 | empty |
| 3 | 223 | 0.48 | 0.74 | 31 | empty |
| 4 | 122 | 0.36 | 0.73 | 25 | empty |
| 5 | 82 | 0.32 | 0.74 | 17 | empty |
Interfaces
7 interfaces between chains.
- G–H · 2147 Ų buried · 13 hydrogen bonds · protein-protein
- I–J · 1992 Ų buried · 9 hydrogen bonds · protein-protein
- G–I · 591 Ų buried · 5 hydrogen bonds · protein-protein
- B–H · 515 Ų buried · 7 hydrogen bonds · protein-protein
- B–I · 459 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 4Z2M · Crystal structure of human SPT16 Mid-AID/H3-H4 tetramer FACT Histone complex · the same entry in another collection · chain B against B, TM-score 1.00
- Q9Y5B9 · AlphaFold monomer V2.0 prediction for fact complex subunit SPT16 (Q9Y5B9) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y5B9
- Every structure of UniProt P68431
- Every structure of UniProt P62805
- Elsewhere: RCSB PDB 4Z2M · PDBe 4Z2M · UniProt Q9Y5B9 · UniProt P68431 · UniProt P62805
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