MolNFT v1 · #110533 · protein
Structure of yeast importin a bound to the membrane protein nuclear localization signal sequence of inm protein HEH1
4XZR · Inner nuclear membrane protein SRC1: “Structure of yeast importin a bound to the membrane protein nuclear localization signal sequence of inm…”. X-ray diffraction, 3 pockets (best druggability 0.40). MolNFT v1 #110533 on GenesisL1…
- PDB
- 4XZR
- Type
- protein
- Length
- 441 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inner nuclear membrane protein SRC1; Importin subunit alpha
- UniProt
- Q03707, Q02821
- Pockets
- 3 · best druggability 0.40
Structure
x-ray diffraction · 2 distinct chains · 67% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Inner nuclear membrane protein SRC1 | protein | 18 | 0% helix, 0% strand | Q03707 |
| B | Importin subunit alpha | protein | 423 | 70% helix, 0% strand | Q02821 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 70 | 0.40 | 0.79 | 22 | empty |
| 2 | 58 | 0.35 | 0.78 | 14 | empty |
| 3 | 52 | 0.33 | 0.78 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1459 Ų buried · 39 hydrogen bonds · protein-protein
Compared structures
- 4XZR · Structure of yeast importin a bound to the membrane protein Nuclear Localization Signal… · the same entry in another collection · chain A against A, TM-score 1.00
- Q02821 · AlphaFold monomer V2.0 prediction for importin subunit alpha (Q02821) · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q03707 · AlphaFold monomer V2.0 prediction for inner nuclear membrane protein SRC1 (Q03707) · a predicted model of the same protein · chain A against A, TM-score 0.15
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03707
- Every structure of UniProt Q02821
- Elsewhere: RCSB PDB 4XZR · PDBe 4XZR · UniProt Q03707 · UniProt Q02821
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