MolNFT v1 · #109685 · protein
Crystal structure of the coiled-coil surrounding skip 4 of MYH7
4XA6 · GP7-MYH7(1777-1855)-EB1 chimera protein: “Crystal structure of the coiled-coil surrounding skip 4 of MYH7”. X-ray diffraction, 4 pockets (best druggability 0.52). MolNFT v1 #109685 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4XA6
- Type
- protein
- Length
- 554 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GP7-MYH7(1777-1855)-EB1 chimera protein
- UniProt
- P13848, P12883, Q15691
- Pockets
- 4 · best druggability 0.52
Structure
x-ray diffraction · 4 distinct chains · 80% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GP7-MYH7(1777-1855)-EB1 chimera protein | protein | 168 | 82% helix, 0% strand | P13848, P12883, Q15691 |
| B | GP7-MYH7(1777-1855)-EB1 chimera protein | protein | 165 | 79% helix, 0% strand | P13848, P12883, Q15691 |
| C | GP7-MYH7(1777-1855)-EB1 chimera protein | protein | 116 | 76% helix, 0% strand | P13848, P12883, Q15691 |
| D | GP7-MYH7(1777-1855)-EB1 chimera protein | protein | 105 | 82% helix, 0% strand | P13848, P12883, Q15691 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 229 | 0.52 | 0.76 | 25 | empty |
| 2 | 66 | 0.28 | 0.73 | 17 | empty |
| 3 | 78 | 0.28 | 0.71 | 17 | empty |
| 4 | 59 | 0.27 | 0.73 | 12 | empty |
Interfaces
6 interfaces between chains.
- A–B · 4571 Ų buried · 31 hydrogen bonds · protein-protein
- C–D · 2882 Ų buried · 13 hydrogen bonds · protein-protein
- A–D · 448 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 278 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 270 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 66 modified (methylation, engineered).
Compared structures
- 4XA6 · Crystal Structure of the coiled-coil surrounding Skip 4 of MYH7 · the same entry in another collection · chain D against D, TM-score 1.00
- P12883 · AlphaFold monomer V2.0 prediction for myosin-7 (P12883) · a predicted model of the same protein · chain D against A, TM-score 0.69
- Q15691 · AlphaFold monomer V2.0 prediction for microtubule-associated protein RP/EB family member… · a predicted model of the same protein · chain D against A, TM-score 0.58
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13848
- Every structure of UniProt P12883
- Every structure of UniProt Q15691
- Elsewhere: RCSB PDB 4XA6 · PDBe 4XA6 · UniProt P13848 · UniProt P12883 · UniProt Q15691
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.