MolNFT v1 · #109682 · protein
Crystal structure of the coiled-coil surrounding skip 2 of MYH7
4XA3 · GP7-MYH7(1361-1425)-EB1 chimera protein: “Crystal structure of the coiled-coil surrounding skip 2 of MYH7”. X-ray diffraction, 1 pocket (best druggability 0.41). MolNFT v1 #109682 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4XA3
- Type
- protein
- Length
- 284 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GP7-MYH7(1361-1425)-EB1 chimera protein
- UniProt
- P13848, P12883, Q15691
- Pockets
- 1 · best druggability 0.41
Structure
x-ray diffraction · 2 distinct chains · 90% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GP7-MYH7(1361-1425)-EB1 chimera protein | protein | 142 | 92% helix, 0% strand | P13848, P12883, Q15691 |
| B | GP7-MYH7(1361-1425)-EB1 chimera protein | protein | 142 | 89% helix, 0% strand | P13848, P12883, Q15691 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 55 | 0.41 | 0.81 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 3787 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 4XA3 · Crystal structure of the coiled-coil surrounding Skip 2 of MYH7 · the same entry in another collection · chain B against B, TM-score 1.00
- P12883 · AlphaFold monomer V2.0 prediction for myosin-7 (P12883) · a predicted model of the same protein · chain B against A, TM-score 0.67
- Q15691 · AlphaFold monomer V2.0 prediction for microtubule-associated protein RP/EB family member… · a predicted model of the same protein · chain A against A, TM-score 0.40
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13848
- Every structure of UniProt P12883
- Every structure of UniProt Q15691
- Elsewhere: RCSB PDB 4XA3 · PDBe 4XA3 · UniProt P13848 · UniProt P12883 · UniProt Q15691
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