MolNFT v1 · #109470 · protein
Crystal structure of 34 kda F-actin bundling protein from dictyostelium discoideum
4X3N · Calcium-regulated actin-bundling protein: “Crystal structure of 34 kda F-actin bundling protein from dictyostelium discoideum”. X-ray diffraction, 1 ligand (CA), 9 pockets (best druggability 0.76). MolNFT v1 #109470 on GenesisL1: 3D…
- PDB
- 4X3N
- Type
- protein
- Length
- 772 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium-regulated actin-bundling protein
- UniProt
- P24005
- Ligands
- CA
- Pockets
- 9 · best druggability 0.76
Structure
x-ray diffraction · 3 distinct chains · 76% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calcium-regulated actin-bundling protein | protein | 259 | 74% helix, 2% strand | P24005 |
| B | Calcium-regulated actin-bundling protein | protein | 255 | 77% helix, 2% strand | P24005 |
| C | Calcium-regulated actin-bundling protein | protein | 258 | 76% helix, 2% strand | P24005 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 491 | 0.76 | 0.84 | 47 | empty |
| 2 | 525 | 0.75 | 0.83 | 51 | empty |
| 3 | 463 | 0.73 | 0.83 | 45 | empty |
| 4 | 452 | 0.69 | 0.80 | 53 | CIT |
| 5 | 331 | 0.57 | 0.76 | 43 | empty |
Interfaces
3 interfaces between chains.
- A–B · 565 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 563 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 539 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 4X3N · Crystal structure of 34 kDa F-actin bundling protein from Dictyostelium discoideum · the same entry in another collection · chain A against A, TM-score 1.00
- P24005 · AlphaFold monomer V2.0 prediction for calcium-regulated actin- bundling protein (P24005) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24005
- Elsewhere: RCSB PDB 4X3N · PDBe 4X3N · UniProt P24005
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