MolNFT v1 · #10916 · protein

Uncomplexed actin

1J6Z · Actin alpha 1: “Uncomplexed actin”. X-ray diffraction, 3 ligands (ADP, RHO, CA), 2 pockets (best druggability 0.71). MolNFT v1 #10916 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1J6Z
Type: protein
Length: 369 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Actin alpha 1
UniProt: P68135
Ligands: ADP, RHO, CA
Pockets: 2 · best druggability 0.71

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Actin alpha 1	protein	369	44% helix, 19% strand	P68135

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · chains A
RHO · Tetramethylrhodamine-5-maleimide · ligand · chains A
CA · Calcium ion · metal · 6 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	389	0.71	0.83	55	CA, ADP
2	278	0.60	0.78	34	RHO

Modifications

Observed in the structure: 1 modified (methylation).

Compared structures

1J6Z · Uncomplexed actin · the same entry in another collection · chain A against A, TM-score 1.00
P68135 · AlphaFold monomer V2.0 prediction for actin, alpha skeletal muscle (P68135) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P68135
Elsewhere: RCSB PDB 1J6Z · PDBe 1J6Z · UniProt P68135

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