MolNFT v1 · #108548 · protein

The crystal structure of neuraminidase from a H3N8 influenza virus isolated from new england harbor seals

4WA3: “The crystal structure of neuraminidase from a H3N8 influenza virus isolated from new england harbor seals”. X-ray diffraction, 4 ligands (NAG, FUC, CA), 1 pocket (best druggability 0.64). MolNFT v1 #108548 on GenesisL1: 3D…

PDB: 4WA3
Type: protein
Length: 388 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neuraminidase
UniProt: I6NW33
Ligands: NAG, FUC, CA, NI
Pockets: 1 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 4% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Neuraminidase	protein	388	4% helix, 47% strand	I6NW33

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A
FUC · alpha-L-fucopyranose · sugar · chains A
CA · Calcium ion · metal · chains A
NI · Nickel (II) ion · metal

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	381	0.64	0.79	41	empty

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

4WA3 · The crystal structure of neuraminidase from a H3N8 influenza virus isolated from New… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt I6NW33
Elsewhere: RCSB PDB 4WA3 · PDBe 4WA3 · UniProt I6NW33

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