MolNFT v1 · #10819 · protein

Crystal structure of drosophila ance

1J36 · Angiotensin converting enzyme: “Crystal structure of drosophila ance”. X-ray diffraction, 2 ligands (LPR, ZN), 10 pockets (best druggability 0.86). MolNFT v1 #10819 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1J36
Type: protein
Length: 1,196 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Angiotensin converting enzyme
EC: 3.4.15.1
UniProt: Q10714
Ligands: LPR, ZN
Pockets: 10 · best druggability 0.86

Structure

x-ray diffraction · 1 distinct chain · 59% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Angiotensin converting enzyme (EC 3.4.15.1)	protein	598	59% helix, 4% strand	Q10714

Ligands and binding sites

LPR · [N2-[(S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline · ligand · 2 copies · chains A, B
ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1126	0.86	0.87	121	LPR
2	560	0.85	0.91	68	LPR
3	535	0.65	0.77	52	empty
4	87	0.60	0.88	18	empty
5	59	0.51	0.87	17	empty

Interfaces

1 interface between chains.

A–B · 541 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

1J36 · Crystal Structure of Drosophila AnCE · the same entry in another collection · chain A against A, TM-score 1.00
Q10714 · AlphaFold monomer V2.0 prediction for angiotensin-converting enzyme (Q10714) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q10714
Elsewhere: RCSB PDB 1J36 · PDBe 1J36 · UniProt Q10714

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.