MolNFT v1 · #107963 · protein + DNA
Crystal structure of PC4 W89Y mutant complex with DNA
4USG · Activated RNA polymerase II transcriptional coactivator P15: “Crystal structure of PC4 W89Y mutant complex with DNA”. X-ray diffraction, 1 pocket (best druggability 0.31). MolNFT v1 #107963 on GenesisL1: 3D structure, binding sites…
- PDB
- 4USG
- Type
- protein + DNA
- Length
- 146 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Activated RNA polymerase II transcriptional coactivator P15…
- UniProt
- P53999
- Pockets
- 1 · best druggability 0.31
Structure
x-ray diffraction · 2 distinct chains · 27% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Activated RNA polymerase II transcriptional coactivator P15 | protein | 66 | 27% helix, 52% strand | P53999 |
| C | 5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP *TP*TP*TP*TP*TP*G)-3' | dna | 14 | — | — |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 63 | 0.31 | 0.75 | 13 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1472 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 982 Ų buried · 15 hydrogen bonds · protein-nucleic
- B–C · 821 Ų buried · 11 hydrogen bonds · protein-nucleic
Compared structures
- 4USG · Crystal structure of PC4 W89Y mutant complex with DNA · the same entry in another collection · chain A against A, TM-score 1.00
- P53999 · AlphaFold monomer V2.0 prediction for activated RNA polymerase II transcriptional… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53999
- Elsewhere: RCSB PDB 4USG · PDBe 4USG · UniProt P53999
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