Ternary crystal structure of the PYGO2 phd finger in complex with the B9L HD1 domain and a H3K4ME2 peptide

Structure

x-ray diffraction · 2 distinct chains · 31% helix, 18% strand (DSSP).

Ligands and binding sites

• ZN · Zinc ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–F · 490 Ų buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (methylation).

Compared structures

• 4UP0 · Ternary crystal structure of the Pygo2 PHD finger in complex with the B9L HD1 domain and… · the same entry in another collection · chain A against A, TM-score 1.00
• Q9BRQ0 · AlphaFold monomer V2.0 prediction for pygopus homolog 2 (Q9BRQ0) · a predicted model of the same protein · chain A against A, TM-score 0.66
• Q86UU0 · AlphaFold monomer V2.0 prediction for B-cell CLL/LYMPHOMA 9-like protein (Q86UU0) · a predicted model of the same protein · chain A against A, TM-score 0.27

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9BRQ0
• Every structure of UniProt Q86UU0
• Every structure of UniProt P68431
• Elsewhere: RCSB PDB 4UP0 · PDBe 4UP0 · UniProt Q9BRQ0 · UniProt Q86UU0 · UniProt P68431