MolNFT v1 · #107621 · protein
Low resolution structure R-spondin-2 (FU1FU2) in complex with the ectodomains of LGR5 and ZNRF3
4UFS · Leucine-rich repeat-containing G-protein coupled receptor 5: “Low resolution structure R-spondin-2 (FU1FU2) in complex with the ectodomains of LGR5 and ZNRF3”. X-ray diffraction, 7 pockets (best druggability 0.81). MolNFT v1 #107621…
- PDB
- 4UFS
- Type
- protein
- Length
- 716 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leucine-rich repeat-containing G-protein coupled receptor 5; R-spondin-2; E3…
- EC
- 6.3.2.-
- UniProt
- O75473, Q8BFU0, Q5SSZ7
- Pockets
- 7 · best druggability 0.81
Structure
x-ray diffraction · 3 distinct chains · 8% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leucine-rich repeat-containing G-protein coupled receptor 5 | protein | 460 | 5% helix, 18% strand | O75473 |
| B | R-spondin-2 | protein | 103 | 0% helix, 50% strand | Q8BFU0 |
| C | E3 ubiquitin-protein ligase ZNRF3 (EC 6.3.2.-) | protein | 153 | 22% helix, 35% strand | Q5SSZ7 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 798 | 0.81 | 0.84 | 92 | empty |
| 2 | 103 | 0.78 | 0.97 | 23 | empty |
| 3 | 179 | 0.62 | 0.83 | 26 | empty |
| 4 | 65 | 0.60 | 0.90 | 18 | empty |
| 5 | 85 | 0.41 | 0.79 | 19 | empty |
Interfaces
3 interfaces between chains.
- B–C · 932 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 907 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 52 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 13 disulfide (disulfide).
Compared structures
- 4UFS · Low resolution structure R-spondin-2 (Fu1Fu2) in complex with the ectodomains of LGR5 and… · the same entry in another collection · chain A against A, TM-score 1.00
- O75473 · AlphaFold monomer V2.0 prediction for leucine-rich repeat-containing G-protein coupled… · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q5SSZ7 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase ZNRF3 (Q5SSZ7) · a predicted model of the same protein · chain C against A, TM-score 0.94
- Q8BFU0 · AlphaFold monomer V2.0 prediction for R-spondin-2 (Q8BFU0) · a predicted model of the same protein · chain B against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75473
- Every structure of UniProt Q8BFU0
- Every structure of UniProt Q5SSZ7
- Elsewhere: RCSB PDB 4UFS · PDBe 4UFS · UniProt O75473 · UniProt Q8BFU0 · UniProt Q5SSZ7
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.