UniProt Q8BFU0
R-spondin-2 (Q8BFU0)
R-spondin-2 (UniProt Q8BFU0): 9 experimental structures and 1 predicted model on GenesisL1, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8BFU0
- Protein
- R-spondin-2
- Experimental structures
- 9
- Predicted models
- 1
- Pockets
- 11 · 3 records with a druggable one
Structures
10 records of Q8BFU0 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4C99 | Mouse ZNRF3 ectodomain in complex with mouse RSPO2 Fu1-Fu2 crystal form I | x-ray diffraction | B, D | — | — |
| 4C99 | Mouse ZNRF3 ectodomain in complex with mouse RSPO2 FU1-FU2 crystal form I | x-ray diffraction | B, D | — | — |
| 4UFR | Structure of the ectodomain of LGR5 in complex with R-spondin-2 (Fu1Fu2) | x-ray diffraction | B, D | — | — |
| 4UFR | Structure of the ectodomain of LGR5 in complex with R-spondin-2 (FU1FU2) | x-ray diffraction | B, D | — | — |
| 4UFS | Low resolution structure R-spondin-2 (Fu1Fu2) in complex with the ectodomains of LGR5 and ZNRF3 | x-ray diffraction | B | — | — |
| 4UFS | Low resolution structure R-spondin-2 (FU1FU2) in complex with the ectodomains of LGR5 and ZNRF3 | x-ray diffraction | B | — | — |
| 8XFP | the pentamerA complex of LGR4-RSPO2-ZNRF3(delta RING) | electron microscopy | G, J | — | 4 (best 0.81) |
| 8XFS | LGR4-RSPO2-ZNRF3 RING domain (1:2:2) | electron microscopy | B, D | — | 4 (best 0.80) |
| 8Y69 | LGR4-RSPO2-ZNRF3 (2:2:2) | electron microscopy | G, J | — | 3 (best 0.83) |
| Q8BFU0 | AlphaFold monomer V2.0 prediction for R-spondin-2 (Q8BFU0) | predicted | A | — | — |
Experiment against prediction
- 4UFR chain B against the predicted model Q8BFU0: TM-score 0.95, RMSD 0.84 Å
- 4UFR chain B against the predicted model Q8BFU0: TM-score 0.95, RMSD 0.84 Å
- 8XFS chain B against the predicted model Q8BFU0: TM-score 0.92, RMSD 1.18 Å
- 8XFP chain G against the predicted model Q8BFU0: TM-score 0.91, RMSD 1.30 Å
- 8Y69 chain J against the predicted model Q8BFU0: TM-score 0.90, RMSD 1.42 Å
- 8Y69 chain G against the predicted model Q8BFU0: TM-score 0.89, RMSD 1.48 Å
- 4UFS chain B against the predicted model Q8BFU0: TM-score 0.88, RMSD 1.46 Å
- 4UFS chain B against the predicted model Q8BFU0: TM-score 0.88, RMSD 1.46 Å
- 4C99 chain B against the predicted model Q8BFU0: TM-score 0.78, RMSD 2.15 Å
- 4C99 chain B against the predicted model Q8BFU0: TM-score 0.78, RMSD 2.15 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.