UniProt Q5SSZ7
E3 ubiquitin-protein ligase ZNRF3 (Q5SSZ7)
E3 ubiquitin-protein ligase ZNRF3 (UniProt Q5SSZ7): 22 experimental structures and 1 predicted model on GenesisL1, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q5SSZ7
- Protein
- E3 ubiquitin-protein ligase ZNRF3
- Experimental structures
- 22
- Predicted models
- 1
- Pockets
- 1 · 0 records with a druggable one
Structures
23 records of Q5SSZ7 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4C86 | mouse ZNRF3 ectodomain crystal form I | x-ray diffraction | A, B | — | — |
| 4C86 | Mouse ZNRF3 ectodomain crystal form I | x-ray diffraction | A, B | — | — |
| 4C8A | mouse ZNRF3 ectodomain crystal form II | x-ray diffraction | A, B, C | — | — |
| 4C8A | Mouse ZNRF3 ectodomain crystal form II | x-ray diffraction | A, B, C | — | — |
| 4C8C | mouse ZNRF3 ectodomain crystal form III | x-ray diffraction | A, B | — | — |
| 4C8C | Mouse ZNRF3 ectodomain crystal form III | x-ray diffraction | A, B | — | — |
| 4C8F | mouse ZNRF3 ectodomain crystal form IV | x-ray diffraction | A, B, C, D | — | — |
| 4C8F | Mouse ZNRF3 ectodomain crystal form IV | x-ray diffraction | A, B, C, D | — | — |
| 4C8P | mouse ZNRF3 ectodomain crystal form V, disulfide-bridged S90C variant | x-ray diffraction | A | — | — |
| 4C8P | Mouse ZNRF3 ectodomain crystal form V, disulfide-bridged S90C variant | x-ray diffraction | A | — | — |
| 4C99 | Mouse ZNRF3 ectodomain in complex with mouse RSPO2 Fu1-Fu2 crystal form I | x-ray diffraction | A, C | — | — |
| 4C99 | Mouse ZNRF3 ectodomain in complex with mouse RSPO2 FU1-FU2 crystal form I | x-ray diffraction | A, C | — | — |
| 4C9A | Mouse ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 (Seleno Met) crystal form I | x-ray diffraction | A, C | — | — |
| 4C9A | Mouse ZNRF3 ectodomain in complex with xenopus RSPO2 FU1- FU2 (seleno met) crystal form I | x-ray diffraction | A, C | — | — |
| 4C9E | Mouse ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 (Seleno Met) crystal form II | x-ray diffraction | A, C, E, G | — | — |
| 4C9E | Mouse ZNRF3 ectodomain in complex with xenopus RSPO2 FU1- FU2 (seleno met) crystal form II | x-ray diffraction | A, C, E, G | — | — |
| 4CDJ | Structure of ZNRF3 ectodomain | x-ray diffraction | A, B | — | — |
| 4CDJ | Structure of ZNRF3 ectodomain | x-ray diffraction | A, B | — | — |
| 4CDK | Structure of ZNRF3-RSPO1 | x-ray diffraction | A, B, C, D | — | — |
| 4CDK | Structure of ZNRF3-RSPO1 | x-ray diffraction | A, B, C, D | — | — |
| 4UFS | Low resolution structure R-spondin-2 (Fu1Fu2) in complex with the ectodomains of LGR5 and ZNRF3 | x-ray diffraction | C | — | — |
| 4UFS | Low resolution structure R-spondin-2 (FU1FU2) in complex with the ectodomains of LGR5 and ZNRF3 | x-ray diffraction | C | — | — |
| Q5SSZ7 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase ZNRF3 (Q5SSZ7) | predicted | A | — | 1 (best 0.47) |
Experiment against prediction
- 4C8P chain A against the predicted model Q5SSZ7: TM-score 0.97, RMSD 0.79 Å
- 4C8P chain A against the predicted model Q5SSZ7: TM-score 0.97, RMSD 0.79 Å
- 4C8F chain B against the predicted model Q5SSZ7: TM-score 0.97, RMSD 0.83 Å
- 4C8F chain B against the predicted model Q5SSZ7: TM-score 0.97, RMSD 0.83 Å
- 4C8F chain C against the predicted model Q5SSZ7: TM-score 0.97, RMSD 0.84 Å
- 4C8F chain C against the predicted model Q5SSZ7: TM-score 0.97, RMSD 0.84 Å
- 4C8F chain A against the predicted model Q5SSZ7: TM-score 0.97, RMSD 0.86 Å
- 4C8F chain A against the predicted model Q5SSZ7: TM-score 0.97, RMSD 0.86 Å
- 4C8A chain A against the predicted model Q5SSZ7: TM-score 0.97, RMSD 0.99 Å
- 4C8A chain A against the predicted model Q5SSZ7: TM-score 0.97, RMSD 0.99 Å
Elsewhere
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