MolNFT v1 · #107569 · protein
Complex of D. melanogaster EIF4E with the 4E binding protein thor
4UE8 · Eukaryotic translation initiation factor 4E: “Complex of D. melanogaster EIF4E with the 4E binding protein thor”. X-ray diffraction, 2 ligands (P4G, NA), 1 pocket (best druggability 0.34). MolNFT v1 #107569 on GenesisL1: 3D…
- PDB
- 4UE8
- Type
- protein
- Length
- 199 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 4E; 4E-binding protein thor
- UniProt
- P48598, Q9XZ56
- Ligands
- P4G, NA
- Pockets
- 1 · best druggability 0.34
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 4E | protein | 162 | 33% helix, 34% strand | P48598 |
| B | 4E-binding protein thor | protein | 37 | 30% helix, 3% strand | Q9XZ56 |
Ligands and binding sites
- P4G · 1-ethoxy-2-(2-ethoxyethoxy)ethane · ligand · chains A, B
- NA · Sodium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 71 | 0.34 | 0.76 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1490 Ų buried · 28 hydrogen bonds · protein-protein
Compared structures
- 4UE8 · Complex of D. melanogaster eIF4E with the 4E binding protein Thor · the same entry in another collection · chain A against A, TM-score 1.00
- P48598 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E1… · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q9XZ56 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E-binding… · a predicted model of the same protein · chain B against A, TM-score 0.75
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48598
- Every structure of UniProt Q9XZ56
- Elsewhere: RCSB PDB 4UE8 · PDBe 4UE8 · UniProt P48598 · UniProt Q9XZ56
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