MolNFT v1 · #10699 · protein

Role of B13 glu in insulin assembly: the hexamer structure of recombinant mutant (B13 glu-> gln) insulin

1IZA: “Role of B13 glu in insulin assembly: the hexamer structure of recombinant mutant (B13 glu-> gln) insulin”. X-ray diffraction, 1 pocket (best druggability 0.30). MolNFT v1 #10699 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 1IZA
Type: protein
Length: 102 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Insulin
UniProt: P01315
Pockets: 1 · best druggability 0.30

Structure

x-ray diffraction · 2 distinct chains · 57% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Insulin	protein	21	48% helix, 0% strand	P01315
B, D	Insulin	protein	30	63% helix, 10% strand	P01315

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	70	0.30	0.74	10	empty

Interfaces

4 interfaces between chains.

C–D · 832 Å² buried · 10 hydrogen bonds · protein-protein
B–D · 642 Å² buried · 7 hydrogen bonds · protein-protein
A–B · 555 Å² buried · 2 hydrogen bonds · protein-protein
B–C · 59 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

1IZA · Role of B13 glu in insulin assembly: the hexamer structure of recombinant mutant (B13… · the same entry in another collection · chain A against A, TM-score 1.00
P01315 · AlphaFold monomer V2.0 prediction for insulin (P01315) · a predicted model of the same protein · chain B against A, TM-score 0.49

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01315
Elsewhere: RCSB PDB 1IZA · PDBe 1IZA · UniProt P01315

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