Research workbench
Role of B13 glu in insulin assembly: the hexamer structure of recombinant mutant (B13 glu-> gln) insulin
Analyse Role of B13 glu in insulin assembly: the hexamer structure of recombinant… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1IZA
- Type
- protein
- Length
- 102 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin
- UniProt
- P01315
- Pockets
- 1 · best druggability 0.30
Structure
x-ray diffraction · 2 distinct chains · 57% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Insulin | protein | 21 | 48% helix, 0% strand | P01315 |
| B, D | Insulin | protein | 30 | 63% helix, 10% strand | P01315 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 70 | 0.30 | 0.74 | 10 | empty |
Interfaces
4 interfaces between chains.
- C–D · 832 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 642 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 555 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 59 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 1IZA · Role of B13 glu in insulin assembly: the hexamer structure of recombinant mutant (B13… · the same entry in another collection · chain A against A, TM-score 1.00
- P01315 · AlphaFold monomer V2.0 prediction for insulin (P01315) · a predicted model of the same protein · chain B against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01315
- Elsewhere: RCSB PDB 1IZA · PDBe 1IZA · UniProt P01315
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