UniProt P01315
Insulin A chain (P01315)
Insulin A chain (UniProt P01315): 80 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P01315
- Protein
- Insulin A chain
- Experimental structures
- 80
- Predicted models
- 1
- Ligands
- 6
Structures
81 records of P01315 in the MolNFT archive: 80 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1B17 | PH affects glu B13 switching and sulfate binding in cubic insulin crystals (pH 5.00 coordinates) | x-ray diffraction | A, B | — | — |
| 1B17 | PH affects glu B13 switching and sulfate binding in cubic insulin crystals (pH 5.00 coordinates) | x-ray diffraction | A, B | — | — |
| 1B18 | PH affects glu B13 switching and sulfate binding in cubic insulin crystals (pH 5.53 coordinates) | x-ray diffraction | A, B | — | — |
| 1B18 | PH affects glu B13 switching and sulfate binding in cubic insulin crystals (pH 5.53 coordinates) | x-ray diffraction | A, B | — | — |
| 1B19 | PH affects glu B13 switching and sulfate binding in cubic insulin crystals (pH 5.80 coordinates) | x-ray diffraction | A, B | — | — |
| 1B19 | PH affects glu B13 switching and sulfate binding in cubic insulin crystals (pH 5.80 coordinates) | x-ray diffraction | A, B | — | — |
| 1B2A | PH affects glu B13 switching and sulfate binding in cubic insulin crystals (pH 6.00 coordinates) | x-ray diffraction | A, B | — | — |
| 1B2A | PH affects glu B13 switching and sulfate binding in cubic insulin crystals (pH 6.00 coordinates) | x-ray diffraction | A, B | — | — |
| 1B2B | PH affects glu B13 switching and sulfate binding in cubic insulin crystals (pH 6.16 coordinates) | x-ray diffraction | A, B | — | — |
| 1B2B | PH affects glu B13 switching and sulfate binding in cubic insulin crystals (pH 6.16 coordinates) | x-ray diffraction | A, B | — | — |
| 1B2C | PH affects glu B13 switching and sulfate binding in cubic insulin crystals (pH 6.26 coordinates) | x-ray diffraction | A, B | — | — |
| 1B2C | PH affects glu B13 switching and sulfate binding in cubic insulin crystals (pH 6.26 coordinates) | x-ray diffraction | A, B | — | — |
| 1B2D | PH affects glu B13 switching and sulfate binding in cubic insulin crystals (pH 6.35 coordinates) | x-ray diffraction | A, B | — | — |
| 1B2D | PH affects glu B13 switching and sulfate binding in cubic insulin crystals (pH 6.35 coordinates) | x-ray diffraction | A, B | — | — |
| 1B2E | PH affects glu B13 switching and sulfate binding in cubic insulin crystals (pH 6.50 coordinates) | x-ray diffraction | A, B | — | — |
| 1B2E | PH affects glu B13 switching and sulfate binding in cubic insulin crystals (pH 6.50 coordinates) | x-ray diffraction | A, B | — | — |
| 1B2F | PH affects glu B13 switching and sulfate binding in cubic insulin crystals (pH 6.98 coordinates) | x-ray diffraction | A, B | — | — |
| 1B2F | PH affects glu B13 switching and sulfate binding in cubic insulin crystals (pH 6.98 coordinates) | x-ray diffraction | A, B | — | — |
| 1B2G | PH affects glu B13 switching and sulfate binding in cubic insulin crystals (pH 9.00 coordinates) | x-ray diffraction | A, B | — | — |
| 1B2G | PH affects glu B13 switching and sulfate binding in cubic insulin crystals (pH 9.00 coordinates) | x-ray diffraction | A, B | — | — |
| 1DEI | Desheptapeptide (B24-B30) insulin | x-ray diffraction | A, B, C, D | — | — |
| 1DEI | Desheptapeptide (B24-B30) insulin | x-ray diffraction | A, B, C, D | — | — |
| 1IZA | Role of B13 glu in insulin assembly: the hexamer structure of recombinant mutant (B13 glu-> gln)… | x-ray diffraction | A, B, C, D | — | — |
| 1IZA | Role of B13 glu in insulin assembly: the hexamer structure of recombinant mutant (B13 glu-> gln)… | x-ray diffraction | A, B, C, D | — | — |
| 1IZB | Role of B13 glu in insulin assembly: the hexamer structure of recombinant mutant (B13 glu-> gln)… | x-ray diffraction | A, B, C, D | — | — |
| 1IZB | Role of B13 glu in insulin assembly: the hexamer structure of recombinant mutant (B13 glu-> gln)… | x-ray diffraction | A, B, C, D | — | — |
| 1M5A | Crystal Structure of 2-Co(2+)-Insulin at 1.2A Resolution | x-ray diffraction | A, B, C, D | — | — |
| 1M5A | Crystal structure of 2-CO(2+)-insulin at 1.2A resolution | x-ray diffraction | A, B, C, D | — | — |
| 1MPJ | X-ray crystallographic studies on hexameric insulins in the presence of helix-stabilizing agents… | x-ray diffraction | A, B, C, D | — | — |
| 1MPJ | X-ray crystallographic studies on hexameric insulins in the presence of helix-stabilizing agents… | x-ray diffraction | A, B, C, D | — | — |
| 1SDB | Porcine DESB1-2 DESPENTAPEPTIDE(B26-B30) insulin | x-ray diffraction | A, B | — | — |
| 1SDB | Porcine DESB1-2 DESPENTAPEPTIDE(B26-B30) insulin | x-ray diffraction | A, B | — | — |
| 1WAV | Crystal structure of form B monoclinic crystal of insulin | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1WAV | Crystal structure of form B monoclinic crystal of insulin | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1ZEI | Cross-linked B28 asp insulin | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1ZEI | Cross-linked B28 asp insulin | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1ZNI | INSULIN | x-ray diffraction | A, B, C, D | — | — |
| 1ZNI | INSULIN | x-ray diffraction | A, B, C, D | — | — |
| 2EFA | Neutron crystal structure of cubic insulin at pD6.6 | neutron diffraction | A, B | — | — |
| 2EFA | Neutron crystal structure of cubic insulin at PD6.6 | neutron diffraction | A, B | — | — |
| 2G4M | Insulin collected at 2.0 A wavelength | x-ray diffraction | A, B | — | — |
| 2G4M | Insulin collected at 2.0 a wavelength | x-ray diffraction | A, B | — | — |
| 2TCI | X-ray crystallographic studies on hexameric insulins in the presence of helix-stabilizing agents… | x-ray diffraction | A, B, C, D | — | — |
| 2TCI | X-ray crystallographic studies on hexameric insulins in the presence of helix-stabilizing agents… | x-ray diffraction | A, B, C, D | — | — |
| 2ZPP | Neutron crystal structure of cubic insulin at pD9 | neutron diffraction | A, B | — | — |
| 2ZPP | Neutron crystal structure of cubic insulin at PD9 | neutron diffraction | A, B | — | — |
| 3FHP | A neutron crystallographic analysis of a porcine 2Zn insulin at 2.0 A resolution | neutron diffraction | A, B, C, D | — | — |
| 3FHP | A neutron crystallographic analysis of a porcine 2ZN insulin at 2.0 a resolution | neutron diffraction | A, B, C, D | — | — |
| 3GKY | The Structural Basis of an ER Stress-Associated Bottleneck in a Protein Folding Landscape | x-ray diffraction | A, B, C, D | — | — |
| 3GKY | The structural basis of an er stress-associated bottleneck in a protein folding landscape | x-ray diffraction | A, B, C, D | — | — |
| 3INS | Structure of insulin. results of joint neutron and X-ray refinement | x-ray diffraction, neutron diffraction | A, B, C, D | — | — |
| 3INS | Structure of insulin. results of joint neutron and X-ray refinement | x-ray diffraction; neutron diffraction | A, B, C, D | — | — |
| 3MTH | X-ray crystallographic studies on hexameric insulins in the presence of helix-stabilizing agents… | x-ray diffraction | A, B, C, D | — | — |
| 3MTH | X-ray crystallographic studies on hexameric insulins in the presence of helix-stabilizing agents… | x-ray diffraction | A, B, C, D | — | — |
| 3RTO | Acoustically mounted porcine insulin microcrystals yield an X-ray SAD structure | x-ray diffraction | A, B, C, D | — | — |
| 3RTO | Acoustically mounted porcine insulin microcrystals yield an X-ray sad structure | x-ray diffraction | A, B, C, D | — | — |
| 3T2A | TMAO-grown cubic insulin (porcine) | x-ray diffraction | A, B | — | — |
| 3T2A | Tmao-grown cubic insulin (porcine) | x-ray diffraction | A, B | — | — |
| 4A7E | X-ray crystal structure of porcine insulin flash-cooled at high pressure | x-ray diffraction | A, B | — | — |
| 4A7E | X-ray crystal structure of porcine insulin flash-cooled at high pressure | x-ray diffraction | A, B | — | — |
21 records more on the page itself.
Ligands
Experiment against prediction
- 1WAV chain B against the predicted model P01315: TM-score 0.50, RMSD 1.84 Å
- 2TCI chain B against the predicted model P01315: TM-score 0.49, RMSD 1.94 Å
- 1IZA chain B against the predicted model P01315: TM-score 0.49, RMSD 1.38 Å
- 1IZA chain B against the predicted model P01315: TM-score 0.49, RMSD 1.38 Å
- 1ZNI chain B against the predicted model P01315: TM-score 0.49, RMSD 1.94 Å
- 1MPJ chain B against the predicted model P01315: TM-score 0.48, RMSD 1.32 Å
- 3MTH chain B against the predicted model P01315: TM-score 0.47, RMSD 1.34 Å
- 1DEI chain B against the predicted model P01315: TM-score 0.42, RMSD 1.37 Å
- 1DEI chain B against the predicted model P01315: TM-score 0.42, RMSD 1.37 Å
- 1SDB chain B against the predicted model P01315: TM-score 0.40, RMSD 1.63 Å
Elsewhere
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