MolNFT v1 · #106495 · protein

Gelsolin nanobody shielding mutant plasma gelsolin from furin proteolysis

4S10: “Gelsolin nanobody shielding mutant plasma gelsolin from furin proteolysis”. X-ray diffraction, 1 ligand (CA), 1 pocket (best druggability 0.26). MolNFT v1 #106495 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4S10
Type: protein
Length: 456 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gelsolin nanobody; Gelsolin
UniProt: P06396
Ligands: CA
Pockets: 1 · best druggability 0.26

Structure

x-ray diffraction · 4 distinct chains · 15% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Gelsolin nanobody	protein	127	5% helix, 49% strand	—
C	Gelsolin	protein	101	28% helix, 31% strand	P06396
B	Gelsolin nanobody	protein	126	5% helix, 47% strand	—
D	Gelsolin	protein	102	27% helix, 30% strand	P06396

Ligands and binding sites

CA · Calcium ion · metal · 2 copies · chains C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	58	0.26	0.73	14	empty

Interfaces

3 interfaces between chains.

A–C · 645 Å² buried · 18 hydrogen bonds · protein-protein
B–D · 629 Å² buried · 18 hydrogen bonds · protein-protein
C–B · 15 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

4S10 · Gelsolin nanobody shielding mutant plasma gelsolin from furin proteolysis · the same entry in another collection · chain D against D, TM-score 1.00
P06396 · AlphaFold monomer V2.0 prediction for gelsolin (P06396) · a predicted model of the same protein · chain C against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06396
Elsewhere: RCSB PDB 4S10 · PDBe 4S10 · UniProt P06396

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