MolNFT v1 · #105708 · protein
Structure of AIF2-gamma from sulfolobus solfataricus bound to GDP
4RD6 · Translation initiation factor 2 subunit gamma: “Structure of AIF2-gamma from sulfolobus solfataricus bound to GDP”. X-ray diffraction, 2 ligands (GDP, MG), 6 pockets (best druggability 0.58). MolNFT v1 #105708 on GenesisL1: 3D…
- PDB
- 4RD6
- Type
- protein
- Length
- 405 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Translation initiation factor 2 subunit gamma
- UniProt
- Q980A5
- Ligands
- GDP, MG
- Pockets
- 6 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain · 18% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Translation initiation factor 2 subunit gamma | protein | 405 | 18% helix, 41% strand | Q980A5 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 341 | 0.58 | 0.76 | 43 | empty |
| 2 | 293 | 0.57 | 0.77 | 41 | empty |
| 3 | 130 | 0.45 | 0.77 | 24 | empty |
| 4 | 122 | 0.42 | 0.76 | 24 | empty |
| 5 | 94 | 0.39 | 0.77 | 15 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4RD6 · Structure of aIF2-gamma from Sulfolobus solfataricus bound to GDP · the same entry in another collection · chain A against A, TM-score 1.00
- Q980A5 · AlphaFold monomer V2.0 prediction for translation initiation factor 2 subunit gamma… · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q980A5
- Elsewhere: RCSB PDB 4RD6 · PDBe 4RD6 · UniProt Q980A5
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.