MolNFT v1 · #105285 · protein

Crystal structure of the poliovirus RNA-dependent RNA polymerase low- fidelity mutant 3DPOL H273R

4R0E · RNA-directed RNA polymerase: “Crystal structure of the poliovirus RNA-dependent RNA polymerase low- fidelity mutant 3DPOL H273R”. X-ray diffraction, 4 pockets (best druggability 0.60). MolNFT v1 #105285 on GenesisL1: 3D structure…

PDB: 4R0E
Type: protein
Length: 461 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-directed RNA polymerase
EC: 2.7.7.48
UniProt: P03300
Pockets: 4 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA-directed RNA polymerase (EC 2.7.7.48)	protein	461	43% helix, 15% strand	P03300

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	282	0.60	0.79	39	empty
2	279	0.59	0.78	29	empty
3	128	0.55	0.83	34	empty
4	106	0.41	0.76	19	empty

Compared structures

4R0E · Crystal Structure of the Poliovirus RNA-Dependent RNA Polymerase Low-Fidelity Mutant… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03300
Elsewhere: RCSB PDB 4R0E · PDBe 4R0E · UniProt P03300

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