Research workbench
Crystal structure of the poliovirus RNA-dependent RNA polymerase low- fidelity mutant 3DPOL H273R
Analyse Crystal structure of the poliovirus RNA-dependent RNA polymerase low- fidelity… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4R0E
- Type
- protein
- Length
- 461 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-directed RNA polymerase
- EC
- 2.7.7.48
- UniProt
- P03300
- Pockets
- 4 · best druggability 0.60
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA-directed RNA polymerase (EC 2.7.7.48) | protein | 461 | 43% helix, 15% strand | P03300 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 282 | 0.60 | 0.79 | 39 | empty |
| 2 | 279 | 0.59 | 0.78 | 29 | empty |
| 3 | 128 | 0.55 | 0.83 | 34 | empty |
| 4 | 106 | 0.41 | 0.76 | 19 | empty |
Compared structures
- 4R0E · Crystal Structure of the Poliovirus RNA-Dependent RNA Polymerase Low-Fidelity Mutant… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03300
- Elsewhere: RCSB PDB 4R0E · PDBe 4R0E · UniProt P03300
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