MolNFT v1 · #105195 · protein
Crystal structure of human LGR4 and RSPO1
4QXF · Leucine-rich repeat-containing G-protein coupled receptor…: “Crystal structure of human LGR4 and RSPO1”. X-ray diffraction, 4 pockets (best druggability 0.71). MolNFT v1 #105195 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 4QXF
- Type
- protein
- Length
- 758 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leucine-rich repeat-containing G-protein coupled receptor 4, variable lymphocyte receptor…
- UniProt
- Q9BXB1, Q4G1L2, Q2MKA7
- Pockets
- 4 · best druggability 0.71
Structure
x-ray diffraction · 4 distinct chains · 6% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leucine-rich repeat-containing G-protein coupled receptor 4, variable lymphocyte receptor B | protein | 300 | 7% helix, 17% strand | Q9BXB1, Q4G1L2 |
| B | Leucine-rich repeat-containing G-protein coupled receptor 4, variable lymphocyte receptor B | protein | 301 | 7% helix, 17% strand | Q9BXB1, Q4G1L2 |
| E | R-spondin-1 | protein | 78 | 0% helix, 45% strand | Q2MKA7 |
| C | R-spondin-1 | protein | 79 | 0% helix, 44% strand | Q2MKA7 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 645 | 0.71 | 0.78 | 69 | empty |
| 2 | 417 | 0.69 | 0.81 | 37 | empty |
| 3 | 118 | 0.39 | 0.75 | 23 | empty |
| 4 | 105 | 0.36 | 0.74 | 27 | empty |
Interfaces
3 interfaces between chains.
- B–E · 825 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 377 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 191 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 17 disulfide (disulfide).
Compared structures
- 4QXF · crystal structure of human LGR4 and Rspo1 · the same entry in another collection · chain C against C, TM-score 1.00
- Q2MKA7 · AlphaFold monomer V2.0 prediction for R-spondin-1 (Q2MKA7) · a predicted model of the same protein · chain E against A, TM-score 0.93
- Q9BXB1 · AlphaFold monomer V2.0 prediction for leucine-rich repeat-containing G-protein coupled… · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BXB1
- Every structure of UniProt Q4G1L2
- Every structure of UniProt Q2MKA7
- Elsewhere: RCSB PDB 4QXF · PDBe 4QXF · UniProt Q9BXB1 · UniProt Q4G1L2 · UniProt Q2MKA7
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.