UniProt Q9BXB1
Leucine-rich repeat-containing G-protein coupled receptor 4 (Q9BXB1)
Leucine-rich repeat-containing G-protein coupled receptor 4 (UniProt Q9BXB1): 15 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 86 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9BXB1
- Protein
- Leucine-rich repeat-containing G-protein coupled receptor 4
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 86 · 9 records with a druggable one
Structures
16 records of Q9BXB1 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4KT1 | Complex of R-spondin 1 with LGR4 extracellular domain | x-ray diffraction | A | — | — |
| 4KT1 | Complex of R-spondin 1 with LGR4 extracellular domain | x-ray diffraction | A | — | — |
| 4QXE | Crystal structure of LGR4 fused with hagfish VLR | x-ray diffraction | A | — | — |
| 4QXE | Crystal structure of LGR4 fused with hagfish vlr | x-ray diffraction | A | — | — |
| 4QXF | crystal structure of human LGR4 and Rspo1 | x-ray diffraction | A, B | — | — |
| 4QXF | Crystal structure of human LGR4 and RSPO1 | x-ray diffraction | A, B | — | — |
| 8WVU | Cryo-EM structure of LGR4 in complex with Rspo1 and RNF43 | electron microscopy | A | — | 9 (best 0.80) |
| 8WVV | Cryo-EM structure of LGR4 in state I | electron microscopy | A | — | 1 (best 0.39) |
| 8WVW | Cryo-EM structure of LGR4 in state II | electron microscopy | A | — | 2 (best 0.78) |
| 8WVX | Cryo-EM structure of LGR4 in complex with Norrin(dimer) | electron microscopy | A, B | — | 12 (best 0.84) |
| 8WVY | Cryo-EM structure of LGR4 in complex with Norrin | electron microscopy | A | — | 8 (best 0.79) |
| 8XFP | the pentamerA complex of LGR4-RSPO2-ZNRF3(delta RING) | electron microscopy | A | — | 12 (best 0.81) |
| 8XFS | LGR4-RSPO2-ZNRF3 RING domain (1:2:2) | electron microscopy | A | — | 8 (best 0.80) |
| 8XFT | LGR4-RSPO2-ZNRF3(1:1:1) | electron microscopy | A | — | 9 (best 0.78) |
| 8Y69 | LGR4-RSPO2-ZNRF3 (2:2:2) | electron microscopy | A, D | CLR | 19 (best 0.84) |
| Q9BXB1 | AlphaFold monomer V2.0 prediction for leucine-rich repeat-containing G-protein coupled receptor 4… | predicted | A | — | 6 (best 0.81) |
Ligands
- CLR · Cholesterol · in 1 record
Experiment against prediction
- 4KT1 chain A against the predicted model Q9BXB1: TM-score 0.99, RMSD 1.37 Å
- 4KT1 chain A against the predicted model Q9BXB1: TM-score 0.99, RMSD 1.37 Å
- 8WVX chain B against the predicted model Q9BXB1: TM-score 0.97, RMSD 1.54 Å
- 8WVY chain A against the predicted model Q9BXB1: TM-score 0.97, RMSD 1.61 Å
- 8XFP chain A against the predicted model Q9BXB1: TM-score 0.97, RMSD 1.69 Å
- 8WVX chain A against the predicted model Q9BXB1: TM-score 0.97, RMSD 1.63 Å
- 8WVW chain A against the predicted model Q9BXB1: TM-score 0.97, RMSD 1.76 Å
- 8WVV chain A against the predicted model Q9BXB1: TM-score 0.96, RMSD 1.85 Å
- 8WVU chain A against the predicted model Q9BXB1: TM-score 0.96, RMSD 1.86 Å
- 8Y69 chain D against the predicted model Q9BXB1: TM-score 0.96, RMSD 1.90 Å
Elsewhere
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