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MolNFT v1 · #105194 · protein

Crystal structure of LGR4 fused with hagfish vlr

4QXE · Leucine-rich repeat-containing G-protein coupled receptor…: “Crystal structure of LGR4 fused with hagfish vlr”. X-ray diffraction, 3 ligands (NAG, CL, SO4). MolNFT v1 #105194 on GenesisL1: 3D structure, binding sites and pockets in…

PDB
4QXE
Type
protein
Length
443 residues
Chains
1
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Leucine-rich repeat-containing G-protein coupled receptor 4, linker, variable lymphocyte…
UniProt
Q9BXB1, Q4G1L2
Ligands
NAG, CL, SO4

Structure

x-ray diffraction · 1 distinct chain · 6% helix, 18% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ALeucine-rich repeat-containing G-protein coupled receptor 4, linker, variable lymphocyte receptor Bprotein4436% helix, 18% strandQ9BXB1, Q4G1L2

Ligands and binding sites

  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains A
  • CL · Chloride ion · ion · 2 copies · chains A
  • SO4 · Sulfate ion · ion · chains A
  • GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Modifications

Observed in the structure: 5 disulfide, 3 glycan (disulfide, N-glycosylation).

Compared structures

  • 4QXE · Crystal structure of LGR4 fused with hagfish VLR · the same entry in another collection · chain A against A, TM-score 1.00
  • Q9BXB1 · AlphaFold monomer V2.0 prediction for leucine-rich repeat-containing G-protein coupled… · a predicted model of the same protein · chain A against A, TM-score 0.93

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