MolNFT v1 · #105078 · protein
Crystal structure of human JMJD5 jmj-C domain
4QU1 · Lysine-specific demethylase 8: “Crystal structure of human JMJD5 jmj-C domain”. X-ray diffraction, 2 ligands (AKG, NI), 1 pocket (best druggability 0.54). MolNFT v1 #105078 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 4QU1
- Type
- protein
- Length
- 236 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lysine-specific demethylase 8
- EC
- 1.14.11.27
- UniProt
- Q8N371
- Ligands
- AKG, NI
- Pockets
- 1 · best druggability 0.54
Structure
x-ray diffraction · 1 distinct chain · 25% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lysine-specific demethylase 8 (EC 1.14.11.27) | protein | 236 | 25% helix, 33% strand | Q8N371 |
Ligands and binding sites
- AKG · 2-oxoglutaric acid · ligand · chains A
- NI · Nickel (II) ion · metal · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 121 | 0.54 | 0.82 | 25 | NI, AKG |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8N371
- Elsewhere: RCSB PDB 4QU1 · PDBe 4QU1 · UniProt Q8N371
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