MolNFT v1 · #104655 · protein

LC8 - ANA2 (237-246) complex

4QH8 · Dynein light chain 1, cytoplasmic: “LC8 - ANA2 (237-246) complex”. X-ray diffraction, 1 pocket (best druggability 0.72). MolNFT v1 #104655 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4QH8
Type: protein
Length: 529 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dynein light chain 1, cytoplasmic; Anastral spindle 2
UniProt: Q24117, Q9XZ31
Pockets: 1 · best druggability 0.72

Structure

x-ray diffraction · 5 distinct chains · 36% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Dynein light chain 1, cytoplasmic	protein	85	39% helix, 42% strand	Q24117
C	Anastral spindle 2	protein	11	0% helix, 82% strand	Q9XZ31
D	Anastral spindle 2	protein	10	0% helix, 70% strand	Q9XZ31
E, G	Dynein light chain 1, cytoplasmic	protein	85	39% helix, 44% strand	Q24117
F, H	Dynein light chain 1, cytoplasmic	protein	84	39% helix, 45% strand	Q24117

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	783	0.72	0.78	70	empty

Interfaces

12 interfaces between chains.

E–F · 1000 Å² buried · 30 hydrogen bonds · protein-protein
A–B · 955 Å² buried · 30 hydrogen bonds · protein-protein
G–H · 945 Å² buried · 23 hydrogen bonds · protein-protein
A–C · 688 Å² buried · 16 hydrogen bonds · protein-protein
B–D · 670 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

4QH8 · LC8 - Ana2 (237-246) Complex · the same entry in another collection · chain H against H, TM-score 1.00
Q24117 · AlphaFold monomer V2.0 prediction for dynein light chain 1, cytoplasmic (Q24117) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q24117
Every structure of UniProt Q9XZ31
Elsewhere: RCSB PDB 4QH8 · PDBe 4QH8 · UniProt Q24117 · UniProt Q9XZ31

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