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LC8 - ANA2 (237-246) complex

Analyse LC8 - ANA2 (237-246) complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
4QH8
Type
protein
Length
529 residues
Chains
8
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Dynein light chain 1, cytoplasmic; Anastral spindle 2
UniProt
Q24117, Q9XZ31
Pockets
1 · best druggability 0.72

Structure

x-ray diffraction · 5 distinct chains · 36% helix, 46% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
A, BDynein light chain 1, cytoplasmicprotein8539% helix, 42% strandQ24117
CAnastral spindle 2protein110% helix, 82% strandQ9XZ31
DAnastral spindle 2protein100% helix, 70% strandQ9XZ31
E, GDynein light chain 1, cytoplasmicprotein8539% helix, 44% strandQ24117
F, HDynein light chain 1, cytoplasmicprotein8439% helix, 45% strandQ24117

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
17830.720.7870empty

Interfaces

12 interfaces between chains.

  • E–F · 1000 Ų buried · 30 hydrogen bonds · protein-protein
  • A–B · 955 Ų buried · 30 hydrogen bonds · protein-protein
  • G–H · 945 Ų buried · 23 hydrogen bonds · protein-protein
  • A–C · 688 Ų buried · 16 hydrogen bonds · protein-protein
  • B–D · 670 Ų buried · 14 hydrogen bonds · protein-protein

Compared structures

  • 4QH8 · LC8 - Ana2 (237-246) Complex · the same entry in another collection · chain H against H, TM-score 1.00
  • Q24117 · AlphaFold monomer V2.0 prediction for dynein light chain 1, cytoplasmic (Q24117) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

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