MolNFT v1 · #104007 · protein

Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar tetramers

4PXT · Bipolar kinesin krp-130: “Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar tetramers”. X-ray diffraction, 2 pockets (best druggability 0.41). MolNFT v1 #104007 on GenesisL1: 3D structure, binding sites…

PDB: 4PXT
Type: protein
Length: 318 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bipolar kinesin krp-130
UniProt: P46863
Pockets: 2 · best druggability 0.41

Structure

x-ray diffraction · 2 distinct chains · 93% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Bipolar kinesin krp-130	protein	163	94% helix, 0% strand	P46863
B	Bipolar kinesin krp-130	protein	155	92% helix, 0% strand	P46863

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	79	0.41	0.79	18	empty
2	55	0.38	0.80	13	empty

Interfaces

1 interface between chains.

A–B · 2863 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 25 modified (engineered).

Compared structures

4PXT · Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar tetramers · the same entry in another collection · chain A against A, TM-score 1.00
P46863 · AlphaFold monomer V2.0 prediction for kinesin-like protein KLP61F (P46863) · a predicted model of the same protein · chain B against A, TM-score 0.69

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P46863
Elsewhere: RCSB PDB 4PXT · PDBe 4PXT · UniProt P46863

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