Research workbench
Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar tetramers
Analyse Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4PXT
- Type
- protein
- Length
- 318 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bipolar kinesin krp-130
- UniProt
- P46863
- Pockets
- 2 · best druggability 0.41
Structure
x-ray diffraction · 2 distinct chains · 93% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bipolar kinesin krp-130 | protein | 163 | 94% helix, 0% strand | P46863 |
| B | Bipolar kinesin krp-130 | protein | 155 | 92% helix, 0% strand | P46863 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 79 | 0.41 | 0.79 | 18 | empty |
| 2 | 55 | 0.38 | 0.80 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 2863 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 25 modified (engineered).
Compared structures
- 4PXT · Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar tetramers · the same entry in another collection · chain A against A, TM-score 1.00
- P46863 · AlphaFold monomer V2.0 prediction for kinesin-like protein KLP61F (P46863) · a predicted model of the same protein · chain B against A, TM-score 0.69
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P46863
- Elsewhere: RCSB PDB 4PXT · PDBe 4PXT · UniProt P46863
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