MolNFT v1 · #103691 · protein
Crystal structure of the human TYK2 ferm and SH2 domains with an IFNAR1 intracellular peptide
4PO6 · Non-receptor tyrosine-protein kinase TYK2: “Crystal structure of the human TYK2 ferm and SH2 domains with an IFNAR1 intracellular peptide”. X-ray diffraction, 6 pockets (best druggability 0.84). MolNFT v1 #103691 on GenesisL1: 3D…
- PDB
- 4PO6
- Type
- protein
- Length
- 494 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Non-receptor tyrosine-protein kinase TYK2; Interferon ALPHA/BETA receptor 1
- EC
- 2.7.10.2
- UniProt
- P29597, P17181
- Pockets
- 6 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) | protein | 475 | 35% helix, 25% strand | P29597 |
| B | Interferon ALPHA/BETA receptor 1 | protein | 19 | 0% helix, 11% strand | P17181 |
Ligands and binding sites
- GOL · Glycerol · additive · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 270 | 0.84 | 0.95 | 41 | GOL |
| 2 | 320 | 0.63 | 0.79 | 31 | GOL |
| 3 | 76 | 0.39 | 0.78 | 19 | empty |
| 4 | 76 | 0.32 | 0.74 | 20 | empty |
| 5 | 72 | 0.28 | 0.72 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1286 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 4PO6 · Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular… · the same entry in another collection · chain A against A, TM-score 1.00
- P29597 · AlphaFold monomer V2.0 prediction for non-receptor tyrosine-protein kinase TYK2 (P29597) · a predicted model of the same protein · chain A against A, TM-score 1.00
- P17181 · AlphaFold monomer V2.0 prediction for interferon ALPHA/BETA receptor 1 (P17181) · a predicted model of the same protein · chain B against A, TM-score 0.26
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29597
- Every structure of UniProt P17181
- Elsewhere: RCSB PDB 4PO6 · PDBe 4PO6 · UniProt P29597 · UniProt P17181
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