Research workbench
Crystal structure of the human TYK2 ferm and SH2 domains with an IFNAR1 intracellular peptide
Analyse Crystal structure of the human TYK2 ferm and SH2 domains with an IFNAR1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4PO6
- Type
- protein
- Length
- 494 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Non-receptor tyrosine-protein kinase TYK2; Interferon ALPHA/BETA receptor 1
- EC
- 2.7.10.2
- UniProt
- P29597, P17181
- Pockets
- 6 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) | protein | 475 | 35% helix, 25% strand | P29597 |
| B | Interferon ALPHA/BETA receptor 1 | protein | 19 | 0% helix, 11% strand | P17181 |
Ligands and binding sites
- GOL · Glycerol · additive · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 270 | 0.84 | 0.95 | 41 | GOL |
| 2 | 320 | 0.63 | 0.79 | 31 | GOL |
| 3 | 76 | 0.39 | 0.78 | 19 | empty |
| 4 | 76 | 0.32 | 0.74 | 20 | empty |
| 5 | 72 | 0.28 | 0.72 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1286 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 4PO6 · Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular… · the same entry in another collection · chain A against A, TM-score 1.00
- P29597 · AlphaFold monomer V2.0 prediction for non-receptor tyrosine-protein kinase TYK2 (P29597) · a predicted model of the same protein · chain A against A, TM-score 1.00
- P17181 · AlphaFold monomer V2.0 prediction for interferon ALPHA/BETA receptor 1 (P17181) · a predicted model of the same protein · chain B against A, TM-score 0.26
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29597
- Every structure of UniProt P17181
- Elsewhere: RCSB PDB 4PO6 · PDBe 4PO6 · UniProt P29597 · UniProt P17181
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