MolNFT v1 · #103542 · protein
Crystal structure of human stromal antigen 2 (SA2) in complex with sister chromatid cohesion protein 1 (SCC1)
4PJU · Cohesin subunit sa-2: “Crystal structure of human stromal antigen 2 (SA2) in complex with sister chromatid cohesion protein 1 (SCC1)”. X-ray diffraction, 9 pockets (best druggability 0.69). MolNFT v1 #103542 on GenesisL1: 3D…
- PDB
- 4PJU
- Type
- protein
- Length
- 970 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cohesin subunit sa-2; Double-strand-break repair protein RAD21 homolog
- UniProt
- Q8N3U4, O60216
- Pockets
- 9 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 69% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cohesin subunit sa-2 | protein | 896 | 71% helix, 0% strand | Q8N3U4 |
| B | Double-strand-break repair protein RAD21 homolog | protein | 74 | 43% helix, 5% strand | O60216 |
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 546 | 0.69 | 0.78 | 47 | empty |
| 2 | 375 | 0.63 | 0.78 | 42 | empty |
| 3 | 183 | 0.50 | 0.77 | 21 | empty |
| 4 | 81 | 0.43 | 0.80 | 17 | empty |
| 5 | 118 | 0.43 | 0.77 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 3596 Ų buried · 58 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 36 modified (engineered).
Compared structures
- 4PJU · crystal structure of human Stromal Antigen 2 (SA2) in complex with Sister Chromatid… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8N3U4 · AlphaFold monomer V2.0 prediction for cohesin subunit sa-2 (Q8N3U4) · a predicted model of the same protein · chain A against A, TM-score 0.99
- O60216 · AlphaFold monomer V2.0 prediction for double-strand-break repair protein RAD21 homolog… · a predicted model of the same protein · chain B against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8N3U4
- Every structure of UniProt O60216
- Elsewhere: RCSB PDB 4PJU · PDBe 4PJU · UniProt Q8N3U4 · UniProt O60216
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