UniProt O60216
64-kDa C-terminal product (O60216)
64-kDa C-terminal product (UniProt O60216): 36 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 83 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O60216
- Protein
- 64-kDa C-terminal product
- Experimental structures
- 36
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 83 · 15 records with a druggable one
Structures
37 records of O60216 in the MolNFT archive: 36 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4PJU | crystal structure of human Stromal Antigen 2 (SA2) in complex with Sister Chromatid Cohesion… | x-ray diffraction | B | — | — |
| 4PJU | Crystal structure of human stromal antigen 2 (SA2) in complex with sister chromatid cohesion… | x-ray diffraction | B | — | — |
| 4PJW | crystal structure of human Stromal Antigen 2 (SA2) in complex with Sister Chromatid Cohesion… | x-ray diffraction | B | — | — |
| 4PJW | Crystal structure of human stromal antigen 2 (SA2) in complex with sister chromatid cohesion… | x-ray diffraction | B | — | — |
| 4PK7 | crystal structure of human Stromal Antigen 2 (SA2) in complex with Sister Chromatid Cohesion… | x-ray diffraction | B | — | — |
| 4PK7 | Crystal structure of human stromal antigen 2 (SA2) in complex with sister chromatid cohesion… | x-ray diffraction | B | — | — |
| 6QNX | Structure of the SA2/SCC1/CTCF complex | x-ray diffraction | B | — | 3 (best 0.75) |
| 6QNX | Structure of the SA2/SCC1/CTCF complex | x-ray diffraction | B | — | — |
| 6RRC | Crystal structure of the N-terminal region of human cohesin subunit STAG1 in complex with RAD21… | x-ray diffraction | B, D | SO4 | 1 (best 0.47) |
| 6RRC | Crystal structure of the N-terminal region of human cohesin subunit STAG1 in complex with RAD21… | x-ray diffraction | B, D | — | — |
| 6RRK | Crystal structure of the central region of human cohesin subunit STAG1 in complex with RAD21 peptide | x-ray diffraction | C, D | — | 4 (best 0.47) |
| 6RRK | Crystal structure of the central region of human cohesin subunit STAG1 in complex with RAD21 peptide | x-ray diffraction | C, D | — | — |
| 6WG3 | Cryo-EM structure of human Cohesin-NIPBL-DNA complex | electron microscopy | C | — | 8 (best 0.86) |
| 6WG3 | Cryo-EM structure of human cohesin-nipbl-DNA complex | electron microscopy | C | — | — |
| 6WGE | Cryo-EM structure of human Cohesin-NIPBL-DNA complex without STAG1 | electron microscopy | C | — | 8 (best 0.85) |
| 6WGE | Cryo-EM structure of human cohesin-nipbl-DNA complex without STAG1 | electron microscopy | C | — | — |
| 7W1M | Cryo-EM structure of human cohesin-CTCF-DNA complex | electron microscopy | C | — | 6 (best 0.90) |
| 7ZJS | Structural basis of centromeric cohesion protection by SGO1 | x-ray diffraction | B, D | — | 6 (best 0.78) |
| 8K4D | Structure of the SA2/Scc1/CENP_U complex | x-ray diffraction | B | — | 3 (best 0.74) |
| 8P0A | Human Cohesin ATPase module | electron microscopy | C | — | 4 (best 0.54) |
| 8PQ5 | Human Cohesin ATPase module with an open DNA exit gate | electron microscopy | C | — | 3 (best 0.86) |
| 8RO6 | Human cohesin SMC1A-HD(longCC)/RAD21-C complex - Apo closed P-loop conformation | x-ray diffraction | B | — | 1 (best 0.34) |
| 8RO8 | Human cohesin SMC1A-HD(longCC-EQ)/RAD21-C complex - Apo closed P-loop conformation | x-ray diffraction | B | — | 1 (best 0.41) |
| 8RO9 | Human cohesin SMC1A-HD(longCC-EQ)/RAD21-C complex - Open/closed P-loop conformation | x-ray diffraction | B, D | — | 4 (best 0.74) |
| 8ROA | Human cohesin SMC1A-HD(longCC-EQ)/RAD21-C complex - ADP-bound conformation | x-ray diffraction | B, D | — | 3 (best 0.72) |
| 8ROB | Human cohesin SMC1A-HD(longCC-EQ)/RAD21-C complex - ATPgS-Mg-bound conformation | x-ray diffraction | B | — | 1 (best 0.38) |
| 8ROC | Human cohesin SMC1A-HD(shortCC-EQ)/RAD21-C complex - Apo closed P-loop conformation | x-ray diffraction | B | — | 1 (best 0.35) |
| 8ROD | Human cohesin SMC1A-HD(shortCC-EQ)/RAD21-C complex - Open/closed P-loop conformation | x-ray diffraction | B | — | 2 (best 0.37) |
| 8ROE | Human cohesin SMC1A-HD(shortCC-EQ)/RAD21-C complex - ADP-bound conformation | x-ray diffraction | B | — | 1 (best 0.35) |
| 8ROF | Human cohesin SMC1A-HD(shortCC-EQ)/RAD21-C complex - ADP-Mg-bound conformation | x-ray diffraction | B | — | 2 (best 0.36) |
| 8ROG | Human cohesin SMC1A-HD(shortCC-EQ)/RAD21-C complex - ATPgS-Mg-bound conformation | x-ray diffraction | B | — | 2 (best 0.44) |
| 8ROH | Human cohesin SMC3-HD(EQ)/RAD21-N complex - Apo conformation | x-ray diffraction | B | SO4 | 5 (best 0.56) |
| 8ROI | Human cohesin SMC3-HD(EQ)/RAD21-N complex - ADP-bound conformation | x-ray diffraction | B | — | 3 (best 0.64) |
| 8ROJ | Human cohesin SMC3-HD/RAD21-N complex - ADP-Mg-bound conformation | x-ray diffraction | B | — | 2 (best 0.61) |
| 8ROK | Human cohesin SMC3-HD(EQ)/RAD21-N complex - ATP-Mg-bound conformation - Form 1 | x-ray diffraction | B, D | — | 4 (best 0.63) |
| 8ROL | Human cohesin SMC3-HD(EQ)/RAD21-N complex - ATP-Mg-bound conformation - Form 2 | x-ray diffraction | B | — | 3 (best 0.57) |
| O60216 | AlphaFold monomer V2.0 prediction for double-strand-break repair protein RAD21 homolog (O60216) | predicted | A | — | 2 (best 0.33) |
Ligands
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 8ROA chain D against the predicted model O60216: TM-score 0.96, RMSD 0.61 Å
- 8ROI chain B against the predicted model O60216: TM-score 0.95, RMSD 0.76 Å
- 8ROK chain B against the predicted model O60216: TM-score 0.95, RMSD 0.75 Å
- 8ROH chain B against the predicted model O60216: TM-score 0.93, RMSD 1.35 Å
- 8ROJ chain B against the predicted model O60216: TM-score 0.93, RMSD 0.91 Å
- 8ROB chain B against the predicted model O60216: TM-score 0.93, RMSD 0.82 Å
- 8ROL chain B against the predicted model O60216: TM-score 0.93, RMSD 0.92 Å
- 7ZJS chain B against the predicted model O60216: TM-score 0.92, RMSD 0.95 Å
- 8ROK chain D against the predicted model O60216: TM-score 0.92, RMSD 1.21 Å
- 8K4D chain B against the predicted model O60216: TM-score 0.90, RMSD 1.10 Å
Elsewhere
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