Elongation factor TU:TS complex in a near GTP conformation.

Structure

x-ray diffraction · 2 distinct chains · 29% helix, 25% strand (DSSP).

Ligands and binding sites

• GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains A
• PUL · (1S,2S,3E,5E,7E,10S,11S,12S)-12-[(2R,4E,6E,8Z,10R,12E,14E,16Z,18S,19Z)-10,18-dihydroxy-12,16,19-trimethyl-11,22-dioxoox acyclodocosa-4,6,8,12,14,16,19-heptaen-2-yl]-2,11-dihydroxy-1,10-dimethyl-9-oxotrideca-3,5,7-trien-1-yl 6-deoxy-2,4-di-O-methyl-beta-L-galactopyranoside · ligand · chains A
• MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–C · 961 Ų buried · 11 hydrogen bonds · protein-protein

Compared structures

• 4PC7 · Elongation factor Tu:Ts complex in a near GTP conformation. · the same entry in another collection · chain C against C, TM-score 1.00
• P0CE47 · AlphaFold monomer V2.0 prediction for elongation factor tu 1 (P0CE47) · a predicted model of the same protein · chain A against A, TM-score 0.84
• P0A6P1 · AlphaFold monomer V2.0 prediction for elongation factor ts (P0A6P1) · a predicted model of the same protein · chain C against A, TM-score 0.76

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P0CE47
• Every structure of UniProt P0A6P1
• Elsewhere: RCSB PDB 4PC7 · PDBe 4PC7 · UniProt P0CE47 · UniProt P0A6P1