MolNFT v1 · #103242 · protein
A conserved phenylalanine as relay between the 5 helix and the GDP binding region of heterotrimeric G protein
4PAM · Guanine nucleotide-binding protein G(I) subunit alpha-1: “A conserved phenylalanine as relay between the 5 helix and the GDP binding region of heterotrimeric G protein”. X-ray diffraction, 3 ligands (GDP, SO3, CL), 2 pockets (best…
- PDB
- 4PAM
- Type
- protein
- Length
- 337 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(I) subunit alpha-1
- UniProt
- P10824
- Ligands
- GDP, SO3, CL
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(I) subunit alpha-1 | protein | 337 | 50% helix, 13% strand | P10824 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · chains A
- SO3 · Sulfite ion · ion · chains A
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 258 | 0.67 | 0.84 | 39 | GDP, CL |
| 2 | 226 | 0.60 | 0.81 | 30 | CL |
Compared structures
- 4PAM · A conserved phenylalanine as relay between the 5 helix and the GDP binding region of… · the same entry in another collection · chain A against A, TM-score 1.00
- P10824 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10824
- Elsewhere: RCSB PDB 4PAM · PDBe 4PAM · UniProt P10824
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