MolNFT v1 · #103047 · protein

Caught-in-action signaling complex of rig-I 2CARD domain and mavs card domain

4P4H · Probable ATP-dependent RNA helicase DDX58: “Caught-in-action signaling complex of rig-I 2CARD domain and mavs card domain”. X-ray diffraction, 20 pockets (best druggability 0.91). MolNFT v1 #103047 on GenesisL1: 3D structure…

PDB: 4P4H
Type: protein
Length: 2,644 residues
Chains: 21
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable ATP-dependent RNA helicase DDX58; Mitochondrial antiviral-signaling protein…
EC: 3.6.4.13
UniProt: O95786, Q7Z434, P62987
Pockets: 20 · best druggability 0.91

Structure

x-ray diffraction · 6 distinct chains · 54% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, D, E, H	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13)	protein	188	73% helix, 0% strand	O95786
B, C, F, G	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13)	protein	189	70% helix, 0% strand	O95786
I, J, K, L, N, O, P, M	Mitochondrial antiviral-signaling protein	protein	97	72% helix, 0% strand	Q7Z434
S, W	Ubiquitin-60S ribosomal protein L40	protein	71	17% helix, 35% strand	P62987
T, X	Ubiquitin-60S ribosomal protein L40	protein	73	16% helix, 33% strand	P62987
U	Ubiquitin-60S ribosomal protein L40	protein	72	17% helix, 35% strand	P62987

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1105	0.91	0.93	130	empty
2	780	0.89	0.93	87	empty
3	772	0.89	0.93	86	empty
4	612	0.88	0.93	81	empty
5	485	0.86	0.93	72	empty

Interfaces

68 interfaces between chains.

G–H · 1112 Å² buried · 11 hydrogen bonds · protein-protein
C–D · 1111 Å² buried · 13 hydrogen bonds · protein-protein
E–F · 1085 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 1061 Å² buried · 12 hydrogen bonds · protein-protein
B–C · 1013 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

4P4H · Caught-in-action signaling complex of RIG-I 2CARD domain and MAVS CARD domain · the same entry in another collection · chain K against K, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O95786
Every structure of UniProt Q7Z434
Every structure of UniProt P62987
Elsewhere: RCSB PDB 4P4H · PDBe 4P4H · UniProt O95786 · UniProt Q7Z434 · UniProt P62987

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