MolNFT v1 · #102910 · protein
Crystal structure of NHERF2 PDZ1 domain in complex with LPA2
4P0C · NA(+)/H(+) exchange regulatory cofactor nhe…: “Crystal structure of NHERF2 PDZ1 domain in complex with LPA2”. X-ray diffraction, 2 ligands (CL, SCN), 1 pocket (best druggability 0.32). MolNFT v1 #102910 on GenesisL1: 3D structure…
- PDB
- 4P0C
- Type
- protein
- Length
- 88 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NA(+)/H(+) exchange regulatory cofactor nhe- RF2/LYSOPHOSPHATIDIC acid receptor 2…
- UniProt
- Q15599, Q9HBW0
- Ligands
- CL, SCN
- Pockets
- 1 · best druggability 0.32
Structure
x-ray diffraction · 1 distinct chain · 16% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NA(+)/H(+) exchange regulatory cofactor nhe- RF2/LYSOPHOSPHATIDIC acid receptor 2 chimeric protein | protein | 88 | 16% helix, 38% strand | Q15599, Q9HBW0 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 66 | 0.32 | 0.75 | 15 | empty |
Compared structures
- 4P0C · Crystal Structure of NHERF2 PDZ1 Domain in Complex with LPA2 · the same entry in another collection · chain A against A, TM-score 1.00
- Q15599 · AlphaFold monomer V2.0 prediction for NA(+)/H(+) exchange regulatory cofactor nhe-RF2… · a predicted model of the same protein · chain A against A, TM-score 0.91
- Q9HBW0 · AlphaFold monomer V2.0 prediction for lysophosphatidic acid receptor 2 (Q9HBW0) · a predicted model of the same protein · chain A against A, TM-score 0.37
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15599
- Every structure of UniProt Q9HBW0
- Elsewhere: RCSB PDB 4P0C · PDBe 4P0C · UniProt Q15599 · UniProt Q9HBW0
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