MolNFT v1 · #102513 · protein
Crystal structure of human kap-BETA2 bound to the nls of HCC1 (hepato cellular carcinoma protein 1)
4OO6 · Transportin-1: “Crystal structure of human kap-BETA2 bound to the nls of HCC1 (hepato cellular carcinoma protein 1)”. X-ray diffraction, 4 pockets (best druggability 0.43). MolNFT v1 #102513 on GenesisL1: 3D structure, binding sites…
- PDB
- 4OO6
- Type
- protein
- Length
- 844 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transportin-1; RNA-binding protein 39
- UniProt
- Q92973, Q14498
- Pockets
- 4 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transportin-1 | protein | 836 | 78% helix, 0% strand | Q92973 |
| B | RNA-binding protein 39 | protein | 8 | 0% helix, 0% strand | Q14498 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 140 | 0.43 | 0.75 | 25 | empty |
| 2 | 73 | 0.34 | 0.76 | 13 | empty |
| 3 | 57 | 0.32 | 0.76 | 13 | empty |
| 4 | 53 | 0.30 | 0.76 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 655 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 4OO6 · Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma… · the same entry in another collection · chain A against A, TM-score 1.00
- Q92973 · AlphaFold monomer V2.0 prediction for transportin-1 (Q92973) · a predicted model of the same protein · chain A against A, TM-score 0.92
- Q14498 · AlphaFold monomer V2.0 prediction for RNA-binding protein 39 (Q14498) · a predicted model of the same protein · chain B against A, TM-score 0.51
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92973
- Every structure of UniProt Q14498
- Elsewhere: RCSB PDB 4OO6 · PDBe 4OO6 · UniProt Q92973 · UniProt Q14498
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