MolNFT v1 · #102290 · protein

Leopard syndrome-associated SHP2/A461T mutant

4OHD · Tyrosine-protein phosphatase non-receptor type 11: “Leopard syndrome-associated SHP2/A461T mutant”. X-ray diffraction, 6 pockets (best druggability 0.65). MolNFT v1 #102290 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 4OHD
Type: protein
Length: 494 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein phosphatase non-receptor type 11
EC: 3.1.3.48
UniProt: Q06124
Pockets: 6 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48)	protein	494	29% helix, 28% strand	Q06124

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	394	0.65	0.79	40	empty
2	257	0.57	0.78	43	empty
3	257	0.53	0.76	34	empty
4	90	0.50	0.83	23	empty
5	61	0.37	0.79	12	empty

Compared structures

4OHD · LEOPARD Syndrome-Associated SHP2/A461T mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q06124
Elsewhere: RCSB PDB 4OHD · PDBe 4OHD · UniProt Q06124

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