Research workbench
Leopard syndrome-associated SHP2/A461T mutant
Analyse Leopard syndrome-associated SHP2/A461T mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4OHD
- Type
- protein
- Length
- 494 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase non-receptor type 11
- EC
- 3.1.3.48
- UniProt
- Q06124
- Pockets
- 6 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) | protein | 494 | 29% helix, 28% strand | Q06124 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 394 | 0.65 | 0.79 | 40 | empty |
| 2 | 257 | 0.57 | 0.78 | 43 | empty |
| 3 | 257 | 0.53 | 0.76 | 34 | empty |
| 4 | 90 | 0.50 | 0.83 | 23 | empty |
| 5 | 61 | 0.37 | 0.79 | 12 | empty |
Compared structures
- 4OHD · LEOPARD Syndrome-Associated SHP2/A461T mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06124
- Elsewhere: RCSB PDB 4OHD · PDBe 4OHD · UniProt Q06124
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