MolNFT v1 · #102051 · protein

Crystal structure of E. COLI lactose permease G46W,G262W bound to sugar

4OAA · LACTOSE/GALACTOSE transporter: “Crystal structure of E. COLI lactose permease G46W,G262W bound to sugar”. X-ray diffraction, 2 ligands (YIO, GAL), 9 pockets (best druggability 0.86). MolNFT v1 #102051 on GenesisL1: 3D structure…

PDB: 4OAA
Type: protein
Length: 782 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: LACTOSE/GALACTOSE transporter
UniProt: B1XBJ1
Ligands: YIO, GAL
Pockets: 9 · best druggability 0.86

Structure

x-ray diffraction · 1 distinct chain · 80% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	LACTOSE/GALACTOSE transporter	protein	391	80% helix, 0% strand	B1XBJ1

Ligands and binding sites

YIO · 1-thio-beta-D-galactopyranose · ligand · 2 copies · chains A, B
GAL · beta-D-galactopyranose · sugar · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1124	0.86	0.86	83	YIO, GAL
2	1123	0.84	0.85	80	YIO, GAL
3	291	0.51	0.73	40	empty
4	222	0.49	0.74	26	empty
5	69	0.46	0.82	15	empty

Interfaces

1 interface between chains.

A–B · 682 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

4OAA · Crystal structure of E. coli lactose permease G46W,G262W bound to sugar · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B1XBJ1
Elsewhere: RCSB PDB 4OAA · PDBe 4OAA · UniProt B1XBJ1

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.