Research workbench
Crystal structure of E. COLI lactose permease G46W,G262W bound to sugar
Analyse Crystal structure of E. COLI lactose permease G46W,G262W bound to sugar in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4OAA
- Type
- protein
- Length
- 782 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- LACTOSE/GALACTOSE transporter
- UniProt
- B1XBJ1
- Ligands
- YIO, GAL
- Pockets
- 9 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 80% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | LACTOSE/GALACTOSE transporter | protein | 391 | 80% helix, 0% strand | B1XBJ1 |
Ligands and binding sites
- YIO · 1-thio-beta-D-galactopyranose · ligand · 2 copies · chains A, B
- GAL · beta-D-galactopyranose · sugar · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1124 | 0.86 | 0.86 | 83 | YIO, GAL |
| 2 | 1123 | 0.84 | 0.85 | 80 | YIO, GAL |
| 3 | 291 | 0.51 | 0.73 | 40 | empty |
| 4 | 222 | 0.49 | 0.74 | 26 | empty |
| 5 | 69 | 0.46 | 0.82 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 682 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4OAA · Crystal structure of E. coli lactose permease G46W,G262W bound to sugar · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B1XBJ1
- Elsewhere: RCSB PDB 4OAA · PDBe 4OAA · UniProt B1XBJ1
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