MolNFT v1 · #101257 · protein

Poliovirus polymerase - C290V loop mutant

4NLP · RNA-directed RNA polymerase 3D-pol: “Poliovirus polymerase - C290V loop mutant”. X-ray diffraction, 1 ligand (NA), 3 pockets (best druggability 0.64). MolNFT v1 #101257 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4NLP
Type: protein
Length: 461 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-directed RNA polymerase 3D-pol
EC: 2.7.7.48
UniProt: P03300
Ligands: NA
Pockets: 3 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA-directed RNA polymerase 3D-pol (EC 2.7.7.48)	protein	461	42% helix, 15% strand	P03300

Ligands and binding sites

NA · Sodium ion · metal · chains A
ACY · Acetic acid · additive · 5 copies · chains A
1PE · Pentaethylene glycol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	497	0.64	0.76	58	empty
2	234	0.57	0.79	28	empty
3	65	0.36	0.77	14	empty

Modifications

Observed in the structure: 3 modified (artifact).

Compared structures

4NLP · Poliovirus Polymerase - C290V Loop Mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03300
Elsewhere: RCSB PDB 4NLP · PDBe 4NLP · UniProt P03300

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