MolNFT v1 · #10114 · protein
Structure of the C-domain of human cardiac troponin C in complex with CA2+ sensitizer emd 57033
1IH0 · Troponin C, slow skeletal and cardiac muscles: “Structure of the C-domain of human cardiac troponin C in complex with CA2+ sensitizer emd 57033”. Solution nmr, 2 ligands (EMD, CA), 1 pocket (best druggability 0.55). MolNFT v1 #10114…
- PDB
- 1IH0
- Type
- protein
- Length
- 71 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Troponin C, slow skeletal and cardiac muscles
- UniProt
- P63316
- Ligands
- EMD, CA
- Pockets
- 1 · best druggability 0.55
Structure
solution nmr · 1 distinct chain · 51% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Troponin C, slow skeletal and cardiac muscles | protein | 71 | 51% helix, 6% strand | P63316 |
Ligands and binding sites
- EMD · 5-[1-(3,4-dimethoxy-benzoyl)-1,2,3,4-tetrahydro-quinolin-6-yl]-6-methyl-3,6-dihydro-[1,3,4]thiadiazin-2-one · ligand · chains A
- CA · Calcium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 94 | 0.55 | 0.84 | 17 | EMD |
Compared structures
- 1IH0 · Structure of the C-domain of Human Cardiac Troponin C in Complex with Ca2+ Sensitizer EMD… · the same entry in another collection · chain A against A, TM-score 1.00
- P63316 · AlphaFold monomer V2.0 prediction for troponin C, slow skeletal and cardiac muscles… · a predicted model of the same protein · chain A against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63316
- Elsewhere: RCSB PDB 1IH0 · PDBe 1IH0 · UniProt P63316
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