MolNFT v1 · #100842 · protein
Crystal structure of saccharomyces cerevisiae UPC2 transcription factor fused with T4 lysozyme
4N9N · Sterol uptake control protein 2, lysozyme: “Crystal structure of saccharomyces cerevisiae UPC2 transcription factor fused with T4 lysozyme”. X-ray diffraction, 10 pockets (best druggability 0.76). MolNFT v1 #100842 on GenesisL1: 3D…
- PDB
- 4N9N
- Type
- protein
- Length
- 856 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sterol uptake control protein 2, lysozyme
- UniProt
- Q12151, P00720
- Pockets
- 10 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 61% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Sterol uptake control protein 2, lysozyme | protein | 428 | 61% helix, 4% strand | Q12151, P00720 |
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 756 | 0.76 | 0.81 | 62 | empty |
| 2 | 958 | 0.76 | 0.79 | 67 | empty |
| 3 | 221 | 0.68 | 0.85 | 22 | empty |
| 4 | 53 | 0.42 | 0.82 | 19 | empty |
| 5 | 74 | 0.35 | 0.76 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 832 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 22 modified (engineered).
Compared structures
- 4N9N · Crystal Structure of Saccharomyces cerevisiae Upc2 Transcription Factor fused with T4… · the same entry in another collection · chain A against A, TM-score 1.00
- Q12151 · AlphaFold monomer V2.0 prediction for sterol uptake control protein 2 (Q12151) · a predicted model of the same protein · chain A against A, TM-score 0.56
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12151
- Every structure of UniProt P00720
- Elsewhere: RCSB PDB 4N9N · PDBe 4N9N · UniProt Q12151 · UniProt P00720
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