MolNFT v1 · #489112 · protein

AlphaFold monomer V2.0 prediction for sterol uptake control protein 2 (Q12151)

Q12151: “AlphaFold monomer V2.0 prediction for sterol uptake control protein 2 (Q12151)”. 6 pockets (best druggability 0.80). MolNFT v1 #489112 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q12151
Type: protein
Length: 913 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x5c4adF1416281C09AE8eE1cbb80fF7e44cE86F97
Molecule: Sterol uptake control protein 2
UniProt: Q12151
Pockets: 6 · best druggability 0.80

Structure

1 distinct chain · 35% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sterol uptake control protein 2	protein	913	35% helix, 3% strand	Q12151

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	788	0.80	0.83	75	empty
2	112	0.76	0.95	23	empty
3	201	0.60	0.81	22	empty
4	106	0.56	0.84	18	empty
5	130	0.41	0.75	24	empty

Compared structures

4N9N · Crystal Structure of Saccharomyces cerevisiae Upc2 Transcription Factor fused with T4… · an experimental structure of the same protein · chain A against A, TM-score 0.28
4N9N · Crystal structure of saccharomyces cerevisiae UPC2 transcription factor fused with T4… · an experimental structure of the same protein · chain A against A, TM-score 0.28
7XB5 · Structure of the ligand-binding domain of S. cerevisiae Upc2 in fusion with T4 lysozyme · an experimental structure of the same protein · chain A against A, TM-score 0.23

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q12151
Elsewhere: UniProt Q12151 · AlphaFold DB Q12151

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