MolNFT v1 · #499494 · protein

AlphaFold monomer V2.0 prediction for WEE1-like protein kinase 2 (P0C1S8)

P0C1S8: “AlphaFold monomer V2.0 prediction for WEE1-like protein kinase 2 (P0C1S8)”. 6 pockets (best druggability 0.69). MolNFT v1 #499494 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: P0C1S8
Type: protein
Length: 567 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x57764D56d6101A81058fB5c5E4A885853213A02B
Molecule: WEE1-like protein kinase 2
UniProt: P0C1S8
Pockets: 6 · best druggability 0.69

Structure

1 distinct chain · 27% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	WEE1-like protein kinase 2	protein	567	27% helix, 10% strand	P0C1S8

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	831	0.69	0.75	70	empty
2	239	0.65	0.83	27	empty
3	287	0.51	0.74	33	empty
4	61	0.51	0.86	19	empty
5	66	0.33	0.76	13	empty

Compared structures

5VDK · Crystal structure of human WEE2 kinase domain in complex with MK1775 · an experimental structure of the same protein · chain A against A, TM-score 0.45

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0C1S8
Elsewhere: UniProt P0C1S8 · AlphaFold DB P0C1S8

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